Top Abstract Purchase Related
Home
>
Node
>
Subnode

Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase

Escalante, B.; Sessa, W.C.; Falck, J.R.; Yadagiri, P.; Schwartzman, M.L.

Journal of Pharmacology and Experimental Therapeutics 248(1): 229-232

1989

ISSN/ISBN: 0022-3565
PMID: 2492340
Document Number: 328221
We recently demonstrated that cortical microsomes from spontaneously hypertensive rats metabolize arachidonic acid via cytochrome P450 to omega- and omega-1 hydroxylated compounds, 19- and 20-hydroxyeicosatetraenoic acids (HETE). The vascular activities of 20-HETE and the two isomers of 19-HETE were examined in rat aortic rings. The HETEs produced concentration-dependent contractions of the aortic rings. The contraction elicited by 20-HETE was abolished partially by removal of endothelium and was inhibited completely by treatment with indomethacin and reversed to a relaxation response by treatment with the endoperoxide and thromboxane receptor antagonist SQ 29548. These data suggest that the vascular effects of 20-HETE depend on subsequent metabolism by cyclooxygenase.

Document emailed within 1 workday
Secure & encrypted payments

Jacobs, E.R.; Effros, R.M.; Falck, J.R.; Reddy, K.M.; Campbell, W.B.; Zhu, D. 1999: Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator American Journal of Physiology 276(2): L280-L288
Tang, D.G.; Diglio, C.A.; Honn, K.V. 1994: Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of alpha v beta 3 integrin: a posttranscriptional, protein kinase C- and cytoskeleton-dependent process Cancer Research 54(4): 1119-1129
Bonne, C.; Moneret-Vautrin, D.A.; Wayoff, M.; Descharmes, A.; Gazel, P.; Legrand, A.; Kalt, C. 1985: Arachidonic acid metabolism and inhibition of cyclooxygenase in platelets from asthmatic subjects with aspirin intolerance Annals of Allergy 54(2): 158-160
Wang, M.H.; Guan, H.; Nguyen, X.; Zand, B.A.; Nasjletti, A.; Laniado-Schwartzman, M. 1999: Contribution of cytochrome P-450 4A1 and 4A2 to vascular 20-hydroxyeicosatetraenoic acid synthesis in rat kidneys American Journal of Physiology 276(2): F246-F253
Ishizuka, T.; Ito, O.; Omata, K.; Ito, S. 2004: Role of androgens in the renal production of 20-hydroxyeicosatetraenoic acid in spontaneously hypertensive rats Nihon Jinzo Gakkai Shi 46(7): 685-692
Krilis, S.A.; Macpherson, J.L.; de Carle, D.J.; Daggard, G.E.; Talley, N.A.; Chesterman, C.N. 1986: Small bowel mucosa from celiac patients generates 15-hydroxyeicosatetraenoic acid (15-HETE) after in vitro challenge with gluten Journal of Immunology 137(12): 3768-3771
Nielsen, O.H.; Elmgreen, J.; Thomsen, B.S.; Ahnfelt-Rønne, I.; Wiik, A. 1986: Release of leukotriene B4 and 5-hydroxyeicosatetraenoic acid during phagocytosis of artificial immune complexes by peripheral neutrophils in chronic inflammatory bowel disease Clinical and Experimental Immunology 65(2): 465-471
Ulbricht, B.; Henny, H.; Horstmann, H.; Spring, H.; Faigle, W.; Spiess, E. 1997: Influence of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) on the localization of cathepsin B and cathepsin L in human lung tumor cells European Journal of Cell Biology 74(3): 294-301
Onoe, Y.; Miyaura, C.; Kaminakayashiki, T.; Nagai, Y.; Noguchi, K.; Chen, Q.R.; Seo, H.; Ohta, H.; Nozawa, S.; Kudo, I.; Suda, T. 1996: IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts Journal of Immunology 156(2): 758-764
Paulson, S.K.; Engel, L.; Reitz, B.; Bolten, S.; Burton, E.G.; Maziasz, T.J.; Yan, B.; Schoenhard, G.L. 1999: Evidence for polymorphism in the canine metabolism of the cyclooxygenase 2 inhibitor, celecoxib Drug Metabolism and Disposition: the Biological Fate of Chemicals 27(10): 1133-1142
Rossi, G.P.; Andreis, P.G.; Neri, G.; Tortorella, C.; Pelizzo, M.R.; Sacchetto, A.; Nussdorfer, G.G. 2000: Endothelin-1 stimulates aldosterone synthesis in Conn's adenomas via both A and B receptors coupled with the protein kinase C- and cyclooxygenase-dependent signaling pathways Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research 48(5): 343-350
Masferrer, J.L.; Reddy, S.T.; Zweifel, B.S.; Seibert, K.; Needleman, P.; Gilbert, R.S.; Herschman, H.R. 1994: In vivo glucocorticoids regulate cyclooxygenase-2 but not cyclooxygenase-1 in peritoneal macrophages Journal of Pharmacology and Experimental Therapeutics 270(3): 1340-1344
Cao, H.; Xu, J.; Liu, H.; Meng, F.-B.; Qiu, J.-F.; Wu, Z.-Y. 2006: Influence of nitric oxide synthase and cyclooxygenase blockade on expression of cyclooxygenase and hemodynamics in rats with portal hypertension Hepatobiliary and Pancreatic Diseases International: Hbpd Int 5(4): 564-569
Pinto, A.; Abraham, N.G.; Mullane, K.M. 1987: Arachidonic acid-induced endothelial-dependent relaxations of canine coronary arteries: contribution of a cytochrome P-450-dependent pathway Journal of Pharmacology and Experimental Therapeutics 240(3): 856-863
Krawczuk-Rybak, M.; Wójtowicz, J.; Urban, M. 1992: Lipid metabolism in patients with insulin dependent diabetes. IV. Effect of sex, age, excess body weight, duration of diabetes, insulin dosage and family history on lipid metabolism in patients with insulin dependent diabetes Endokrynologia Polska 43(2): 125-135
Iakovlev, G.M.; Kozhemiakin, L.A.; Rakov, A.L.; Drygin, A.N.; Iakovlev 1991: Intracellular metabolism in patients with insulin-dependent and non-insulin-dependent diabetes mellitus Problemy Endokrinologii 37(2): 11-14
Bekemeier, H.; Hirschelmann, R.; Ramanampison, M.L.; Pantović, D. 1986: Simultaneous and sequential inhibition of the arachidonic acid cascade by inhibitors of phospholipase A2, cyclooxygenase and lipoxygenases in carrageenan edema and adjuvant arthritis in the rat Die Pharmazie 41(6): 406-408
Khisamov, G.Z.; Morozova, G.Z. 1987: The role of enzymes of amino acid and lipid metabolism in Leptospira metabolism Vestnik Akademii Meditsinskikh Nauk SSSR 7: 84-90
Matiushin, I.F.; Boiarinov, G.A.; Bogdarin, I.A. 1981: Effect of nerobolil on higher fatty acid metabolism in the rat liver normally and in disordered protein metabolism Voprosy Meditsinskoi Khimii 27(5): 604-607
Jeske, A.H.; Gangarosa, L.P. 1981: The determination of the vasoactivity of mepivacaine and its isomers Methods and Findings in Experimental and Clinical Pharmacology 3(1): 33-39