Potency testing of killed polio vaccine in rats

Van Steenis, G.; van Wezel, A.L.; Sekhuis, V.M.

Developments in Biological Standardization 47: 119-128

1981


ISSN/ISBN: 0301-5149
PMID: 6262142
Document Number: 3280
Various laboratory animal species were considered for testing the potency of killed poliovaccine. The rat appeared most suitable for obtaining quantitative information by measuring the titre of the antibody response. There was, in general, a good correlation between antibody response in rats and D-antigen titre. This relationship appeared less clear for heat-degraded or long-stored vaccines.

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Potency testing of killed polio vaccine in rats