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Cytolytic activities of benfluron metabolites and loss of transplantability

Miko, M.; Krepelka, J.; Melka, M.

International Journal of Tissue Reactions 11(3): 143-151

1989

ISSN/ISBN: 0250-0868
PMID: 2613458
Document Number: 327987
The cytolytic activity of two benfluron metabolites, namely 7-dihydrobenfluron (DBF) and benfluron N-oxide (NOBF), has been studied using both Ehrlich ascites carcinoma (EAC) and P388 leukaemia cells. DBF showed a considerable cytolytic activity (activity of lactate and malate dehydrogenases, release of protein from the cells into the culture medium, morphological changes) particularly at higher concentrations. The highest concentrations caused a significant prolongation of the survival time of the experimental animals.

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