Pharmacologic evaluation of cardiovascular reflex responses in migraine patients: lack of central sympathetic modulation?
Munari, L.; Milanesi, I.; Silvani, A.; Bussone, G.; Boiardi, A.
Functional Neurology 4(4): 375-378
1989
ISSN/ISBN: 0393-5264 PMID: 2620855 Document Number: 327453
To characterize autonomic imbalance in migraine, we compared the cardiovascular reflex responses of 10 migraineurs and 10 healthy subjects after pharmacological noradrenergic stimulation or inhibition. A battery of 5 autonomic tests was administered on basal conditions as well as after pretreatment with drugs acting at different levels on the noradrenergic pathway: pseudoephedrine, clonidine, guanethidine, indenolol, prazosin. Our data confirm a predominantly sympathetic hypofunction in migraine and provide evidence for an impairment of the central autonomic control.