Nasal absorption of 17 alpha-ethinyloestradiol in the rat
Bawarshi-Nassar, R.N.; Hussain, A.; Crooks, P.A.
Journal of Pharmacy and Pharmacology 41(3): 214-215
1989
ISSN/ISBN: 0022-3573 PMID: 2568456 Document Number: 326660
The bioavailability of 17.alpha.-ethinyloestradiol was determined after intravenous, nasal, and intraduodenal, administration in the rat. The results showed that the bioavailability of nasally-administered and intraduodenally-administered drug was 80-85, and 15-25%, respectively, of that following intravenous administration. The study demonstrates that the nasal route for the administration of 17.alpha.-ethinyloestradiol is superior to the oral route in this species, and may thus provide an alternative for the administration of this drug at lower doses.