Study on rat nasal absorption in situ of borneol based on single pass perfusion method
Song, X.; Du, S.; Lu, Y.; Ma, Y.; Chen, X.; Wang, Y.; Zhang, H.
Zhongguo Zhong Yao Za Zhi 36(18): 2489-2492
2011
ISSN/ISBN: 1001-5302 PMID: 22256751 Document Number: 650009
To investigate the absorption characteristic of borneol. Using single pass perfusion model, the active ingredient of borneol were detected by GC. The drug concentration, perfusion rate and pH value on the absorption of borneol were studied. Perfusion rate on the absorption rate constants (Ka) had significant effects. Drug concentration and pH value on the absorption rate constants had no significant impact. the absorption of borneol is good by nasal. The absorption rate constants of borneol have no effected by drug concentration. The absorption of borneol is via a simple diffusion.