Cysteamine protects against diarrhoea induced by castor oil. this protective effect can be potentiated by SH-alkylator treatment
Ezer, E.; Wagner, T.
Acta Physiologica Hungarica 71(3): 429-433
1988
ISSN/ISBN: 0231-424X PMID: 3421119 Document Number: 326224
Cysteamine given orally or subcutaneously protects against diarrhoea induced by castor oil. Pretreatment with N-EM, an SH-alkylator, does not influence the occurrence of diarrhoea. Furthermore, N-EM pretreatment does not influence the protective effect of loperamide or difenoxilate. However, N-EM pretreatment potentiates the protective effects of cysteamine or indomethacin against diarrhoea. These findings indicate that sulfhydryl-sensitive processes may also be involved in the mechanisms of diarrhoea.