Protective effect of isaxonine against vincristine-induced neuropathy
Duhamel, G.; Parlier, Y.
La Nouvelle Presse Medicale 11(16): 1254-1256
1982
ISSN/ISBN: 0301-1518 PMID: 6285279 Document Number: 185853
A double-blind survey versus a placebo was carried out with C.P.V. protocole on 25 patients treated for lymphosarcoma or reticulosarcoma; its aim was to appraise the preventive action of isaxonine on the appearance of neuropathy induced by vincristine. The frequency of such neuropathy was clearly lower in the isaxonine group (3/10) than in the placebo group (8/10) in a statistically significant manner. The protective effect of isaxonine was particularly striking on tendon reflexes and on the number of motor units recorded at musculus extensor digitirum pedis brevis; on the contrary, the patients treated with the placebo showed real denervation.