Effects of isaxonine on experimentally induced vincristine neuropathy in rabbits
Kowa, H.; Saito, T.
La Nouvelle Presse Medicale 11(16): 1246-1249
1982
ISSN/ISBN: 0301-1518 PMID: 6285278 Document Number: 196972
The effect of isaxonine on neuropathy induced by vincristine in the rabbit was studied using clinical, electrophysiological and histological parameters. Isaxonine protects against early adverse reactions of vincristine administration such as decrease in food consumption and body weight, an alopecia. Motor disturbance was reduced. This protective effect is confirmed by electrophysiological tests (motor latency, muscular strength of tibialis anterior muscle). Isaxonine decrease the incidence of the neuropathy induced by vincristine in the rabbit.