Dibromochloropropane (DBCP) effects on the reproductive function of the adult male rat
Leone, M.; Costa, M.; Capitanio, G.L.; Palmero, S.; Prati, M.; Leone, M.M.
Acta Europaea Fertilitatis 19(2): 99-103
1988
ISSN/ISBN: 0587-2421 PMID: 2906198 Document Number: 325376
In order to evaluate the effect of dipromochloropropane (DBCP) on reproductive function, groups of male adult Wistar rats were injected subcutaneously with different doses of DBCP. A strictly dose-dependent effect resulting in histological alteration principally toward the seminiferous tubules was observed. Sperm count and sperm motility showed azoospermia or oligoasthenospermia with a significative recovery in the lower dose of DBCP treated rats. Among the enzymatic activities evaluated as biochemical markers of testicular function: LDH was not appreciably affected by the DBCP treatment while GGT and NADPH-cyt P450-reductase significantly enhanced suggesting an induction of the detoxification processes.