Morphological study of diet-reversal in rat galactose cataract
Tsutsumi, M.; Terubayashi, H.; Tasaka, H.; Akagi, Y.; Miyamoto, Y.; Ibaraki, N.; Yokoi, N.; Chamoto, K.; Okamoto, S.; Itoi, M.
Nippon Ganka Gakkai Zasshi 92(2): 297-301
1988
ISSN/ISBN: 0029-0203 PMID: 3389280 Document Number: 325117
We fed 25% and 50% galactose chow to SD-strain male immature rats (50g body weight) for 1 or 3 weeks, and then changed the galactose chow to normal chow (diet-reversal). This procedure of diet-reversed seemed to be similar to the administration of one drug, having a completely inhibitory effect on aldose reductase. After diet-reversal, we observed the lenses macro and microscopically. The liquefied anterior cortex was gradually replaced by normal regenerated lens fiber cells, but the posterior cortex showed the progression of destruction of lens fiber cells. Repair occurred from the equator, the anterior cortex, and the posterior cortex.