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Association of liposome-entrapped [3H]methotrexate with thioglycollate-elicited macrophages in-vitro

Foong, W.C.; Green, K.L.

Journal of Pharmacy and Pharmacology 40(3): 171-175

1988

ISSN/ISBN: 0022-3573
PMID: 2899145
Document Number: 324476
The association of free or liposome-entrapped [3H]methotrexate [( 3H]MTX) with thioglycollate-elicited macrophages was investigated in-vitro. [14C]Cholesteryl oleate was incorporated into the liposomes as a lipid marker. [3H]MTX association with the macrophages was 5 to 9-fold higher with liposome-entrapped [3H]MTX than with the free drug. Macrophage-liposome association was biphasic, temperature-dependent and saturable at high liposomal lipid concentration. A high liposome cholesterol (CH) content or the presence of 2,4-dinitrophenol or colchicine also reduced macrophage-liposome association.

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