Experimental study on the therapeutic effect of liposome-entrapped antibiotics in the treatment of destructive pneumonia

Rotov, K.A.; Tikhonov, S.N.; Alekseev, V.V.; Khrapova, N.P.; Snatenkov, E.A.; Zamarin, A.A.; Simakova, N.A.; Rotov, K.A; Tikhonov, S.N; Alekseev, V.V; Khrapova, N.P; Snatenkov, E.A; Zamarin, A.A; Simakova, N.A

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Experimental study on the therapeutic effect of liposome-entrapped antibiotics in the treatment of destructive pneumonia

Rotov, K.A.; Tikhonov, S.N.; Alekseev, V.V.; Khrapova, N.P.; Snatenkov, E.A.; Zamarin, A.A.; Simakova, N.A.

Antibiotiki i Khimioterapiia 50(8-9): 20-22

2005

ISSN/ISBN: 0235-2990

PMID: 17016906

Document Number: 585213

The data on preparation of liposome-entrapped gentamicin sulfate and cefoperazone and their investigation on albino mice with staphylococcal destructive pneumonia are presented. Comparative study of the efficacy of gentamicin sulfate and cefoperazone in free and liposome-entrapped forms showed that immobilization of the antibiotics in phospholipid vesicles provided a 2-fold increase of their efficacy.