Role of the Na+K+-ATPase in the cardiotonic action of cardiac glycosides
Schwartz, A.; Grupp, G.; Wallick, E.; Grupp, I.L.; Ball, W.J.
Progress in Clinical and Biological Research 268b: 321-338
1988
ISSN/ISBN: 0361-7742 PMID: 2851810 Document Number: 324193
In terms of evolution, the Na+,K+-ATPase is one of the oldest proteins. It is intriguing that this membrane-based enzyme has become biologically consistent with a multifunctional protein. One of the most interesting aspects of the Na+,K+-ATPase is that it contains a specific receptor domain for the oldest plant origin cardiotonic drug and that it is involved in the regulation of myocardial contractility.