Intraepithelial and invasive neoplasia of the vulva in association with human papillomavirus infection
Planner, R.S.; Hobbs, J.B.
Journal of Reproductive Medicine 33(6): 503-509
1988
ISSN/ISBN: 0024-7758 PMID: 2841459 Document Number: 324180
Colposcopic examination of 335 women with cytologically detected human papillomavirus (HPV) revealed involvement of the cervix in 316 patients (94%), vagina in 276 (82%) and vulva in 148 (44%). A symptom complex of pruritus and superficial dyspareunia was found in 98 of the 148 patients with vulvar infection (66%). Histologic examination revealed HPV-associated vulvar intraepithelial neoplasia (VIN) in 11 of 148 biopsies (7.4%). Follow-up of the patients with HPV infection with or without VIN showed a spontaneous regression rate of 56% but also demonstrated progression to VIN 3 in two patients and to invasive carcinoma of the vulva in one.
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