Human papillomavirus prevalence, viral load and cervical intraepithelial neoplasia in HIV-infected women
Levi, J.é E.; Fink, M.C.S.; Canto, C.L.M.; Carretiero, N.; Matsubara, R.; Linhares, I.; Das Dores, G.ér.B.; Castelo, A.; Segurado, A.Ãs.; Uip, D.E.; Eluf J, J.é
Brazilian Journal of Infectious Diseases An Official Publication of the Brazilian Society of Infectious Diseases 6(3): 129-135
2002
ISSN/ISBN: 1413-8670 PMID: 12144749 DOI: 10.1590/s1413-86702002000300005Document Number: 241763
HIV-infected women from S o Paulo city were enrolled in a cross-sectional study on Human Papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) prevalence and their association with laboratory markers of AIDS, namely HIV viral load and CD(4)(+) cell counts. A cervical specimen was collected and submitted to Hybrid Capture, a test for HPV viral load determination. HPV-DNA was detected in 173 of 265 women (64.5%). Twenty (7.5%) women were infected by one or more low-risk viruses, 89 (33%) by one or more high-risk viruses, and 64 (24%) harbored at least one HPV type from each risk group. Abnormal smears were observed in 19% of the patients, though there were no invasive carcinomas. Severely immunosuppressed patients (CD(4)/microL <100) were at the greatest risk of having a cytological abnormality and a high high-risk HPV viral load.