In-vitro efficacy of fosfomycin against commonly isolated bacteria
Ngeow, Y.F.; Puthucheary, S.D.
Singapore Medical Journal 29(2): 168-170
1988
ISSN/ISBN: 0037-5675 PMID: 3399920 Document Number: 323592
Fosfomycin, a new antibiotic not related to any antibiotic in use is a small molecule with a simple structure. The in vitro efficacy of this drug against commonly isolated gram positive and gram negative bacteria was studied. Results showed that organisms such as Staphylococcus aureus, both methicillin sensitive and resistant, Haemophilus influenzae, o-haemolytic streptococci, Stococcus typhi, Serratia marcescens, Proteus species, and Pscedomonas aeruginosa were sensitive to fosfomycin. Those exhibiting resistance were F. meningosepticum, Flavobacterium species and Klebsiella species. A third category included Escherichia coli, Steptococcus faecalis and Shigella species which showed intermediate susceptibility. It is possible that fosfomycin may be useful against infections caused by methicillin-resistent Staph. aureus and multiply-resistant Ps. aeruginosa but clinical trials are first necessary to substantiate this.
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