A clinical bacteriological efficacy study on a fosfomycin otic solution
Deguchi, K.; Yokota, N.; Tanaka, S.; Fukayama, S.; Nishimura, Y.; Yoshihara, H.; Oda, S.; Matsumoto, Y.; Ikegami, R.; Sato, K.
Japanese Journal of Antibiotics 39(9): 2344-2354
1986
ISSN/ISBN: 0368-2781 PMID: 3099028 Document Number: 276390
Fosfomycin (FOM) otic solution was administered to 587 patients with suppurative otitis media infections including 190 patients in the dose-establishment test, 126 patients in the open clinical trial and 271 patients in the double blind test. Various bacteria were detected in the 549 cases in which bacteriological investigation was possible. Main bacteria detected from the above cases were Staphylococcus aureus (261 strains, 47.5%), Pseudomonas aeruginosa (93 strains, 16.9%), coagulase negative Staphylococci (CNS) (89 strains, 16.2%), Providenia spp. (35 strains, 6.4%) and Proteus spp. (28 strains, 5.1%). Twenty-seven strains of anaerobic bacteria (4.9%) were also detected.