Ultrasonic coagulometry as a method of testing compounds with antiplasmin activity
Zabelin, N.N.; Gribauskas, P.S.; Moĭseenok, A.G.
Biofizika 33(2): 226-228
1988
ISSN/ISBN: 0006-3029 PMID: 3390473 Document Number: 323314
An ultrasonic interferometer has been used to study the process of fibrin clot lysis according to the decrease in the rate of propagation of an ultrasonic wave in the latter. A significant decrease in the sound fall rate on adding epsilon-aminocaproic and trans-4-aminomethylcyclohexanecarbonic acids to the system indicates their activity inhibiting fibrinolysis. N-nicotinoyl derivatives of this compounds possess less pronounced antiplasmin activity.