Occurrence of Campylobacter pylori in patients with gastritis and peptic ulcer
Carneiro Leão, G.; Magalhães Filho, M.; Galvão, L.P.; Machado, R.C.; Padovan, I.P.; Jucá, N.T.; Lira, V.M.; Magalhães, M.
Arquivos de Gastroenterologia 25(1): 23-28
1988
ISSN/ISBN: 0004-2803 PMID: 3223826 Document Number: 321378
Endoscopic biopsies from the gastric antrum and margin of peptic ulcers (gastric and duodenal) were obtained from 56 patients for histologic and microbiologic studies in order to establish the occurrence of Campylobacter pylori. Thirty nine of them had antral gastritis and in 37 (94.8%) the bacteria was detected. In 17 cases with normal mucosa the culture was positive in only 2 of them (p less than 0.01). Patients with duodenal and gastric ulcer had a 100% and 88.8%, respectively, of positivity to C. pylori at samples from the margin of the lesions. Bacteriologic findings were similar to those described in the literature. At the electronic microscopy bacilli were found near or adhering to the cellular surface without signs of intraepithelial penetration. This study confirms the association between C. pylori and gastritis and peptic gastroduodenal ulcer.