Hepatotoxicosis associated with heartworm/hookworm preventive medication in a dog
Vaden, S.L.; Bunch, S.E.; Duncan, D.E.; Cullen, J.M.
Journal of the American Veterinary Medical Association 192(5): 651-654
1988
ISSN/ISBN: 0003-1488 PMID: 3372315 Document Number: 321296
Diethylcarbamazine/oxibendazole, a medication used to prevent heartworm and hookworm infection in dogs, was believed responsible for an adverse hepatic reaction in a 9-year-old Doberman Pinscher. After 9 weeks of daily drug administration, the dog had clinical signs and diagnostic test results consistent with hepatic failure (high aspartate transaminase, alanine transaminase and alkaline phosphatase activities, and hyperbilirubinaemia and hypoalbuminaemia). Histologic changes compatible with previous hepatic injury were observed in a liver biopsy specimen. Withdrawal of the drug was followed by clinical improvement.