Endogenous opioid system in the realization of the analgesic effect of alpha-tocopherol in reference to algomenorrhea
Kryzhanovskiĭ, G.N.; Bakuleva, L.P.; Luzina, N.L.; Vinogradov, V.A.; Iarygin, K.N.
Biulleten' Eksperimental'noi Biologii i Meditsiny 105(2): 148-150
1988
ISSN/ISBN: 0365-9615 PMID: 2964879 Document Number: 321036
Beta-endorphin-like immunoreactivity was studied in 7 patients with algomenorrhea during pain attack and 15 minutes after alpha-tocopherol administration with a therapeutic aim (till the analgetic effect was reached). There was an increase in beta-endorphin-like immunoreactivity after alpha-tocopherol administration. Naloxone administration to 9 patients with algomenorrhea of various etiology resumed the pain. The effect of alpha-tocopherol application for pain relief depended on the pathogenesis of algomenorrhea. At the same time naloxone administration failed to resume the pain in patients, in whom alpha-tocopherol had a strong analgetic effect. It is assumed that the endogenous opioid system participates in alpha-tocopherol effect on pain relief in patients with algomenorrhea.