Stem cell number versus the fraction synthesizing DNA
Necas, E.; Znojil, V.; Vácha, J.
Experimental Hematology 16(3): 231-234
1988
ISSN/ISBN: 0301-472X PMID: 3338517 Document Number: 320440
It has been widely held that the fraction of spleen colony-forming units (CFU-S) in DNA synthesis is inversely correlated with CFU-S numbers. In 750 measurements the expected negative slope of the linear regression of CFU-S in S phase on CFU-S was found to be significant only when the measurements from irradiated mice were pooled. In contrast, a significant positive correlation was observed when the measurements from normal controls were pooled. A hypothesis is offered to account for the variable relationship between CFU-S and CFU-S in S. The hypothesis fully recognizes the crucial role of both parameters in normal and regenerative hemopoiesis.