The challenge of malaria
Miller, L.H.
Science 257(5066): 36-37
1992
ISSN/ISBN: 0036-8075 PMID: 1621092 DOI: 10.1126/science.1621092Document Number: 319730
Research priorities for control and eradication of malaria are outlined, including the development of vaccines against both the erythrocytic parasite and sporozoite. The elimination of the vector offers another approach for eradication of Plasmodium falciparum and it is suggested that the introduction of genes which kill the parasite or block parasite development may alter the capacity of mosquitoes to transmit malaria. The identification of biochemical pathways and enzymes unique to the parasite, such as the polymerase involved in haemoglobin digestion, may provide targets for drug design.