Bone marrow monosomy 7 in children
Nelken, B.; Lai, J.L.; Facon, T.; Lambilliotte, A.; Gaudier, B.
Archives Francaises de Pediatrie 45(10): 813-814
1988
ISSN/ISBN: 0003-9764 PMID: 3240043 Document Number: 319731
Three new cases of monosomy 7 are described. Two children, before onset of overt leukemia, had a preleukemic state: one with thrombopathy and myelodysplastic syndrome, the other with a moderate splenomegaly and an absolute monocytosis. In these two cases the leukemia was chemoresistant. The last child had a subacute myelomonocytic syndrome (juvenile type of chronic myelogenous leukemia) without high fetal hemoglobin value. She died from cachexia. The poor prognosis of monosomy 7 is underlined and such a chromosome deletion should be searched in myeloproliferative syndrome with monocytosis.