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Specific inhibition of aspartase by S-2,3-dicarboxyaziridine

Higashi, Y.; Tokushige, M.; Umezawa, H.

Biochemistry International 16(3): 449-452

1988

ISSN/ISBN: 0158-5231
PMID: 3289541
Document Number: 319522
Aspartase of Escherichia coli was inhibited in a competitive manner by S-2,3-dicarboxyazirdine (DCAZ), an antibacterial substance against Aeromonas salmonesida. The inhibition constant (Ki) was 55 microM, which was as low as less than one tenth that of the Km value for the substrate, L-aspartate. In view of the fact that both aspartase and fumarase (J. Greenhut et al. (1985) J. Biol. Chem. 260, 6684-6686) were inhibited by DCAZ in competitive manners, common features of the reaction mechanism of the two enzymes were discussed.

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