Tissue-specific inhibition of cellular proliferation in Ehrlich ascites tumor
Romanov, I.A.; Rybakov, V.P.; Antokhin, A.I.; Barysheva, V.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 82(12): 1477-1479
1976
ISSN/ISBN: 0365-9615 PMID: 139183 Document Number: 109684
The extract of cells of ascitic Ehrlich's tumour (chaloun) and its cell-free fluid produced a marked inhibitory action on the cell proliferation of this tumour four hours after the administration. The effect is tissue-specific, more pronounced in the extract and depends on the dose of the antigen. Eight hours after the extract or the cell-free fluid administration the mitotic activity in the tumour proved to increase in comparison with control; this indicated the presence of a short-lived chaloun action on the G2-phase of the mitotic cycle and synchronization of cell division.