A comparison of the behaviour of autologous and homologous platelets in microporous polyurethane grafts. An experimental study in sheep
Dougan, P.; Lannerstad, O.; Bergqvist, D.
Acta Chirurgica Scandinavica 154(3): 185-190
1988
ISSN/ISBN: 0001-5482 PMID: 3376674 Document Number: 319066
In experimental studies in sheep the behaviour of autologous and homologous platelets in microporous polyurethane grafts was compared at a flow rate of 25 ml/min. The grafts were interposed to replace segments of resected carotid arteries. The deposition of 32P-labelled platelets on the graft wall was recorded, as were graft patency, thrombus weight and thrombus-free surface. Compared to autologous platelets, homologous platelets accumulated over longer periods of time and in greater numbers, leading to deposition of larger amounts of thrombus material and reduced patency.