Hemorheologic, metabolic and blood coagulation changes in diabetics in treatment with sulfanyl ureas
Cortinovis, A.; Crippa, A.; Sciacca, V.; Caravaggio, V.; Crippa, M.
Minerva Medica 79(5): 391-398
1988
ISSN/ISBN: 0026-4806 PMID: 3131696 Document Number: 318220
A study was carried out to see if chronic treatment with a sulphanylurea with hypoglycaemic action, with also haemoactive action in terms of anti-platelet aggregation, profibrinolytic and antifibrinogenetic action also acted haemorheologically. For this purpose a group of patients treated with Gliclazide was compared with a group under treatment with Glibenclamide. A significant variation was noted in terms of an increase in erythrocyte filtrability and a diminution in erythrocyte aggregation with diminution in blood viscosity at low shear-rates. The absence of parallel modifications in quantitative corpuscular viscous factors, the early onset of the process, the real diminution in the sense of a reduction below the range of normality suggests that the effect is pharmacological and not mediated by metabolic compensation.