Staining with I-131 labeled 4-iodoalizarin 3-sulfonic acid in vivo, a tracer for growth areas in bone

Schorr, S.; Aviad, I.; Anbar, M.; Rein, R.

American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine 85: 128-132

1961


ISSN/ISBN: 0002-9580
PMID: 13748512
Document Number: 3177
The distribution of 4-iodoalizarin 3-sulfonic acid in various organs has been determined, using l131 labeled dye. The organs examined included liver, spleen, thyroid, kidneys, blood, brain, lungs and muscle, with special reference to bone tissues. It has been found that the labeled dye accumulates in bone, and especially in growing bone formations. The specific activity in bone exceeds that in blood only after most of the dye has been excreted. A comparative examination has been performed determining the accumulation in bone formation of I131 injected as an inorganic iodide. Considering the rate of accumulation, metabolization and excretion of 4-iodozalizarin 3-sulfonic acid, its application as a tracer for the study of physiologic or pathologic new bone formations is impractical.

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Staining with I-131 labeled 4-iodoalizarin 3-sulfonic acid in vivo, a tracer for growth areas in bone