Acute experimental allergic encephalitis. Treatment with fungal polysaccharides
Ceroni, M.; Camana, C.; Franciotta, D.M.; Savoldi, F.; Scelsi, R.; Fumagalli, M.
Il Farmaco; Edizione Scientifica 43(4): 381-387
1988
ISSN/ISBN: 0430-0920 PMID: 3203739 Document Number: 317577
This report describes the effects of a fungal polysaccharide mixture on the Experimental Allergic Encephalitis (EAE) in guinea pigs. The clinical, histopathological and IgG intrathecal synthesis related studies in the EAE sensitized group was compared with that observed in EAE sensitized groups treated with fungal polysaccharides. The results indicate that the fungal polysaccharide mixture is capable of inducing a more localized and milder inflammatory reaction in the guinea pig with EAE. We hypothesize that the fungal polysaccharides can activate complement by the alternative pathway, subtracting it to the specific immune response to EAE.