Clinical and pharmacokinetic study of ceftriaxone in the treatment of 14 episodes of ascitic fluid infection
Ducroix, J.P.; Guerlin, M.; Hary, L.; Smail, A.; Denamur, E.; Eb, F.; Andrejak, M.; Baillet, J.
Pathologie-Biologie 36(8): 1007-1010
1988
ISSN/ISBN: 0369-8114 PMID: 3059283 Document Number: 316765
A clinical study and dosages of ceftriaxone were performed during the treatment of 14 ascitic fluid infections. Fourteen cases of ascitic fluid infection were treated with ceftriaxone at doses of 2 grams daily. The isolation of the causative organisms was obtained in 11 out of 14 cases by systematic culture of the ascitic fluid in hemoculture bottles with aerobic and anaerobic medium. Of 11 evaluable infectious episodes ten were cured. Ceftriaxone diffuses rapidly in the ascitic fluid because, within the first hour; mean concentrations were already of 18.6 micrograms/ml largely exceeding the usual MIC for these organisms. A good tolerance for the drug, the well spaced rythm of infections preventing unnecessary parenteral treatment in cirrhotic patients, and its effectiveness against Enterobacteriaceae justify its choice in the treatment of ascitic fluid infections with sensitive organism.