Clinical and pharmacokinetic study of ceftriaxone in pediatric bacterial infections
Meguro, H.; Nonaka, C.; Kawaoi, T.; Takahashi, S.; Fujii, R.; Arimasu, O.
Japanese Journal of Antibiotics 37(11): 2049-2059
1984
ISSN/ISBN: 0368-2781 PMID: 6098701 Document Number: 240530
Ceftriaxone (Ro 13-9904, CTRX) was evaluated for its safety and efficacy in 33 children with various bacterial infections, including 10 cases of bacteria meningitis. CTRX was effective in all but 1 case who had acute mucositis due to a resistant strain of Enterobacter cloacae. The serum half-life (T1/2.beta.) as 4.5 .+-. 1.6 h after an i.v. bolus injection in children. CSF levels of CTRX in the acute phase of bacterial meningitis were 7.69 .+-. 4.75 .mu./ml. The only side effect was mild to moderate diarrhea observed in 10 of the 33 cases, but in no case was it necessary to discontinue the drug.