The elimination of spermidine from plasma in rats
Emonds, A.; van de Ven, M.; Hermans, J.; Driessen, O.
Methods and Findings in Experimental and Clinical Pharmacology 10(1): 33-37
1988
ISSN/ISBN: 0379-0355 PMID: 3357365 Document Number: 316426
Infused spermidine in rats with bypassed livers was eliminated very slowly, whereas endogenous spermidine in saline-infused controls with bypassed livers increased. In the same animals endogenous putrescine plasma levels did not differ significantly between spermidine- or saline-infused animals, whereas endogenous cadaverine levels increased during spermidine infusion and decreased afterwards. It is concluded that the liver is the most important site for plasma spermidine elimination.
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