Elimination pathway of hematoporphyrin from normal and tumor-bearing rats
Tomio, L.; Zorat, P.L.; Jori, G.; Reddi, E.; Salvato, B.; Corti, L.; Calzavara, F.
Tumori 68(4): 283-286
1982
ISSN/ISBN: 0300-8916 PMID: 7147351 Document Number: 190477
Hematoporphyrin orally administered to rats largely preceipitates in the stomach, thus reaching the various tissues at a very slow rate. Whatever the administration pathway (oral, i.p., i.v.), hemotoporphyrin is eliminated in the feces with no apparent chemical modification; the elimination is slower from rats affected by ascites hepatoma than from normal rats owing to the high affinity of tumor cells for the porphyrin.