Autoregulation of testicular LH receptors in Ames dwarf (df/df) and pigmy (pg/pg) mice
Amador, A.G.; Bartke, A.; Beamer, W.G.; Siler-Khodr, T.M.
Endocrinologia Experimentalis 22(2): 87-97
1988
ISSN/ISBN: 0013-7200 PMID: 3261684 Document Number: 314933
The autoregulation of testicular LH receptors was studied in mutant mice with congenital PRL and GH deficiency (df/df) and in mutant mice with congenital resistance to GH (pg/pg). Low dose of hCG produced an increase in LH receptors in df/df mice, but not in normal mice of the same strain. Intermediate doses of hCG did not affect LH receptors in df/df mice, while decreasing them in normal mice. In pg/pg mice, hCG caused changes in LH receptors which were identical to those observed in their normal siblings. Comparison of these two mutations suggests a lack of involvement of GH in the regulation of testicular LH receptors. Moreover, results obtained from df/df mice could indicate the presence of direct effects of the df mutation on testicular LH receptors.