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Effect on the systemic hemodynamics of polymers that decrease hydrodynamic resistance

Gannushkina, I.V.; Kameneva, M.V.; Antelava, A.L.

Biulleten' Eksperimental'noi Biologii i Meditsiny 106(11): 533-536

1988

ISSN/ISBN: 0365-9615
PMID: 3196847
Document Number: 314930
It has been shown that intravenous injections of drug-reducing polymers (at a dose of 2 x1 0(-6) g/ml) to rabbits produced a decrease in the total peripheral resistance with an increase in the cardiac output and simultaneous diminution of the mean blood pressure. These hemodynamic effects did not depend on vasodilatation as it had previously been shown. The alterations were retained for not less than 72 hours after one polymer injection; the effects were due to the influence of polymers on the flow structure.

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