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Synthesis of hepatic protein during pregnancy in the rat

Harris, J.E.; Kretchmer, N.

Journal of Nutrition 118(11): 1319-1324

1988

ISSN/ISBN: 0022-3166
PMID: 2461439
Document Number: 314022
The accumulation of hepatic protein during pregnancy in the rat could be the result of a decrease in rate of degradation, an increase in rate of synthesis or both. The purpose of the study was to determine relative rates of synthesis of hepatic protein for pregnant and nonpregnant rats. Pregnant and nonpregnant Sprague-Dawley rats were fed a 20% casein, purified diet from the first day of gestation. On d 19 of gestation the rats were killed. Livers were weighed and assayed for RNA. Relative synthesis rates of hepatic protein were assessed by homologous in vitro cell-free translation. RNA per liver and per g liver and incorporation of labeled leucine into protein per liver and per unit of RNA were greater for the pregnant rats than the nonpregnant rats. In conclusion, accumulation of hepatic protein during pregnancy is at least partially the result of an increase in rate of synthesis.

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Kurihara, M.; Miyazaki, M.; Shimura, T.; Takahashi, O.; Okui, K. 1989: Beneficial effects of glucagon-insulin infusion on hepatic protein synthesis and DNA synthesis in partial hepatic ischemia Nihon Geka Gakkai Zasshi 90(7): 1019-1025
Garrett, R.J.; Jackson, M.A. 1979: Effect of acute smoke exposure on hepatic protein synthesis Journal of Pharmacology and Experimental Therapeutics 209(2): 215-218
Kimura, F.; Miyazaki, M.; Suwa, T.; Hayashida, K.; Kakizaki, S.; Ito, H.; Kaiho, T. 1993: Hepatic protein synthesis in regenerating liver after partial hepatectomy Nihon Geka Gakkai Zasshi 94(12): 1263-1268
Borges, D.R.; Manoukian, N. 1987: Evaluation of the hepatic function of protein synthesis in compensated schistosomal liver disease and cirrhosis Amb: Revista da Associacao Medica Brasileira 33(1-2): 3-6
Ueno, S.; Tanabe, G.; Nuruki, K.; Yoshidome, S.; Kubo, F.; Kihara, K.; Aoki, D.; Aikou, T. 2002: Quality of life after hepatectomy in patients with hepatocellular carcinoma: implication of change in hepatic protein synthesis Hepato-Gastroenterology 49(44): 492-496
Matsui, Y.; Asano, T.; Enomoto, K.; Uematsu, T.; Nakagohri, T.; Tokoro, Y.; Jingu, K.; Miyauchi, H.; Maruyama, M.; Iwashita, C. 1994: Graft viability assay for preserved livers using hepatic protein synthesis rates in a rat liver transplantation model Transplantation Proceedings 26(4): 2388-2389
Kleihues, P.; Margison, J.M.; Margison, G.P. 1975: Dimethylnitrosamine-induced inhibition of hepatic protein synthesis in vitro and the effect of pretreatment with cystamine or pregnenolone-16alpha-carbonitrile Cancer Research 35(12): 3667-3672
Gutnikova, M.N.; Shevchenko, N.A.; Boĭkov, P.I.; Mitrokhin, I.I.; Todorov, I.N. 1985: Activation of nuclear polypeptide synthesis in rat liver cells after inhibition of template protein synthesis. the role of nuclear polypeptide synthesis in the changes of the chromatin structure Biokhimiia 50(12): 1990-1996
Thorgeirsson, U.P.; Turpeenniemi-Hujanen, T.; Neckers, L.M.; Johnson, D.W.; Liotta, L.A. 1984: Protein synthesis but not DNA synthesis is required for tumor cell invasion in vitro Invasion and Metastasis 4(2): 73-83
Borová, J.; Fuchs, O.; Hradilek, A.; Neuwirt, J. 1984: Effect of hemin and heme synthesis inhibitors on cellular protein synthesis Biomedica Biochimica Acta 43(1): 11-21
Kudo, M.; Vera, D.R.; Stadalnik, R.C.; Trudeau, W.L.; Ikekubo, K.; Todo, A. 1990: In vivo estimates of hepatic binding protein concentration: correlation with classical indicators of hepatic functional reserve American Journal of Gastroenterology 85(9): 1142-1148
Fradkin, G.E.; Torosian, M.V.; Shishkova, O.V.; Aĭzenberg, O.A.; Rabinkova, E. 1980: Relation between Escherichia coli K-12 viability and mutability and the balance between DNA and protein synthesis. IV. Relation between disruptions in the balance between DNA and protein synthesis and the mutability and viability of cells exposed to ultraviolet and gamma radiation or treated with N-methyl-N-nitroso-N'-nitrosoguanidine Genetika 16(9): 1570-1576
Görmar, F.E.; Bernd, A.; Holzmann, H. 1990: The effect of hydrocortisone aceponate on proliferation, total protein synthesis and collagen synthesis in human skin fibroblasts in vitro Arzneimittel-Forschung 40(2 Part 1): 192-196
Rieber, M.; Bacalao, J. 1974: Selective enhancement of cytoplasmic protein species and continued histone synthesis during inhibition of DNA synthesis in temperature-sensitive Chinese hamster cells Cancer Research 34(11): 3083-3088
Kanda, T.; Takai, K.; Yokoyama, S.; Takaku, H. 1997: Removing tRNA from a cell-free protein synthesis system for use in protein production Nucleic Acids Symposium Series 37: 319-320
Lu, L.; Lin, B. 2010: The cell-free protein synthesis-based protein microarray technology Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 27(6): 1397-1400; 1409
Polonskiĭ, I.S.; Naĭdenova, N.M.; Kozlov, I.I.; Zograf, I.N.; Debabov, V.G. 1977: Influence of protein bound with single-stranded DNA on the synthesis of RNA and poly(A). III. Protein product of F1 gene 5 Molekuliarnaia Biologiia 11(3): 656-660
Atakhanova, B.A.; Kadyrova, K.A.; Saatov, T.S.; Turakulov, I.K. 1977: Protein biosynthesis in a cell-free protein synthesis system from nodular euthyroid goiter cells Voprosy Meditsinskoi Khimii 23(5): 606-608
Khil'ko, S.N. 1974: Induction with estradiol of specific protein synthesis in the rat uterus. 1. Isolation and purification of induced protein from the cytoplasm Problemy Endokrinologii 20(6): 67-71
Nikolaeva, A.I.; Logunova, N.N. 1983: Protein synthesizing structures and protein synthesis in mouse lymphocytes Biokhimiia 48(6): 1042-1051