Relation between Escherichia coli K-12 viability and mutability and the balance between DNA and protein synthesis. IV. Relation between disruptions in the balance between DNA and protein synthesis and the mutability and viability of cells exposed to ultraviolet and gamma radiation or treated with N-methyl-N-nitroso-N'-nitrosoguanidine
Fradkin, G.E.; Torosian, M.V.; Shishkova, O.V.; Aĭzenberg, O.A.; Rabinkova, E.
Genetika 16(9): 1570-1576
1980
ISSN/ISBN: 0016-6758 PMID: 7005028 Document Number: 162208
It has been established that the restoring of the disturbed DNA and protein syntheses balance in cells exposed to UV- and gamma-irradiation or nitrosoguanidine treatment, brought about by the inhibition of the protein synthesis, differently affects mutagenic and lethal effects of these irradiations. In case of UV-irradiation and NG-treatment, inhibition of the protein synthesis increases lethal and decreases mutagenic effects, while gamma-irradiation results in a decrease of both lethal and mutagenic effects. It has been shown that the difference in response to protein synthesis inhibition with respect to mutagenic and lethal effects of UV- and gamma-irradiation is determined by the cell genotype and the nature of the DNA damage.