Multiple hamartoma syndrome
Pujol, R.M.; Ravella, A.; Noguera, X.; de Moragas, J.M.; Moreno, A.
Medicina Cutanea Ibero-Latino-Americana 16(4): 322-327
1988
ISSN/ISBN: 0210-5187 PMID: 3068443 Document Number: 313456
We describe the clinicopathological features of multiple hamartoma and neoplasia syndrome (Cowden's syndrome) in a 58 year-old man and in a 56 year-old woman. The typical mucocutaneous lesions of this disorder were present in both cases. Visceral hamartomas involving thyroid and gastrointestinal system (polyposis) were present in both patients. Dermal or submucous fibromas are proposed as an additional diagnostic criterium of Cowden's syndrome. Associated abnormalities and visceral involvement in multiple hamartoma syndrome are reviewed.