Multiple hamartoma syndrome with osteosarcoma
Yen, B.C.; Kahn, H.; Schiller, A.L.; Klein, M.J.; Phelps, R.G.; Lebwohl, M.G.
Archives of Pathology and Laboratory Medicine 117(12): 1252-1254
1993
ISSN/ISBN: 0003-9985 PMID: 8250698 Document Number: 1082
Multiple hamartoma syndrome, also known as Cowden's disease, is a rare genodermatosis with characteristic muco cutaneous lesions associated with multiple internal abnor malities. We describe a patient having classic dermatologic manifestations of Cowden's disease and multiple neoplasia including follicular adenocarcinoma of the thyroid gland with lung metastasis, intraductal breast carcinoma within a fibroadenoma, and an osteosarcoma. To our knowledge, this is the first reported case of an osteosarcoma in Cowden's disease.
Document emailed within 1 workday
