Progress on nucleic acid-based vaccines for the control of human and animal diseases
Kanellos, T.S.; Ambali, A.G.; Russell, P.H.
Outlook on Agriculture 28(4): 245-252
1999
ISSN/ISBN: 0030-7270 DOI: 10.1177/003072709902800408Document Number: 312599
Among the novel developments in vaccine technology is the use of naked DNA encoding the relevant immunogenic component of pathogens, which has been shown to confer protection on animals. Several advantages, such as stability, stimulation of both cellular and humoral immune responses, and antigen expression over prolonged periods, make DNA vaccines an attractive alternative to conventional ones. This paper highlights the progress made so far with the new technology in terms of its immunogenicity, concerns regarding its safety and future research directions.