Pharmacokinetics of fluorouracil by intravenous or intraarterial injections
Geng, B.Q.; Zhu, Y.L.
Zhongguo Yao Li Xue Bao 9(4): 374-376
1988
ISSN/ISBN: 0253-9756 PMID: 3195350 Document Number: 311870
The high-performance liquid chromatographic analysis of fluorouracil (5-FU) content in blood and colon of rabbits was described. There was no marked differences in the plasma 5-FU level and blood concentration-time curve following iv (ear vein) or ia (inferior mesenteric artery) injections of 5-FU 15 mg/kg. However, the distribution of 5-FU in colon given by ia was quite different from those of iv. At 10, 20 and 30 min after ia, the 5-FU content in colon was shown to be 31-, 17- and 14-fold higher than those of iv, respectively. Colonic tissues AUC0-480 min were 2453 and 690 min .cntdot. mg/ml (p < 0.05). It is suggested that to inject 5-FU into selected arteries to treat advanced colorectal cancer may be helpful.