The plasma level of kanamycin after intravenous and intramuscular injections in horses
Klee, S.; Nürnberger, M.C.; Keller, H.; Ungemach, F.R.
Tierarztliche Praxis 24(4): 368-372
1996
ISSN/ISBN: 0303-6286 PMID: 9012022 Document Number: 463444
A therapeutical dose of kanamycin was tested intravenously and intramuscularly in four normal standardbreds and plasma concentrations were measured over a 12 hour period. Plasma levels exceeded a minimum inhibitory concentration of 4 micrograms/ml within only 15 minutes for 8 hours both after i.v. and i.m. injection. Kanamycin revealed a mean plasma half life of 2.3 hours. Bioavailability of an intramuscular dose was about 76%. The pharmacokinetic parameters demonstrate the rapid onset of antibacterial plasma levels of the test compound. A dose regimen for horses of two times daily 5 mg/kg body weight ensures therapeutically effective plasma levels. The risk of accumulation as well as nephro- or ototoxic side effects are negligible at short-term treatment.