Circulating hematopoietic cells. Results of 6 autologous grafts
Reiffers, J.; Marit, G.; Bernard, P.; David, B.; Sarrat, A.; Chevaleyre, J.; Feuilliatre, F.; Bouzgarrou, R.; Perel, Y.; Vezon, G.
Presse Medicale 17(7): 323-326
1988
ISSN/ISBN: 0755-4982 PMID: 2896349 Document Number: 311356
Six patients with acute non-lymphocytic leukemia underwent autologous transplantation of circulating stem cells collected during remission. They were given cyclophosphamide (120 mg/kg) and total body irradiation (1,000-1,200 rads) (five patients) or busulfan (16 mg/kg) and melphalan (140 mg/m2) before the transfusion of 6.7 X 10(8) nucleated cells/kg corresponding to 19.7 X 10(4) CFU-GM/kg. Granulopoietic engraftment was observed in every case and was influenced by the number of CFU-GM injected. Megakaryocytic recovery was obtained in four cases.