Aldehyde dehydrogenase activity in the barrier brain structures
Zimatkin, S.M.; Ostrovskiĭ, I.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 106(9): 283-284
1988
ISSN/ISBN: 0365-9615 PMID: 3167177 Document Number: 311004
The histochemical method was used to study the aldehyde dehydrogenase (EC 1.2.1.3.; ALDH) activity in capillaries and glial structures of different regions in the rat central nervous system (CNS). The occurrence of three metabolic barriers for aldehydes on systemic level in the CNS has been shown. They are: the barrier between blood and the nervous tissue (represented by capillary endothelium and surrounding astrocytes ALDH), that between blood and cerebrospinal fluid (ALDH in ependymocytes of vascular plexus), and that between cerebrospinal fluid and nervous tissue (ALDH of ependymocytes covering brain cavities). On the single microregions level a similar barrier is between interstitial fluid and neurons (ALDH of satellite oligodendrocytes).