Effect of 25-hydroxyvitamin D3 on Na+-dependent D-glucose transport in rachitic rats
Treves, C.; Favilli, F.; Stio, M.; Iantomasi, T.; Vincenzini, M.T.
Biochemistry International 17(2): 287-301
1988
ISSN/ISBN: 0158-5231 PMID: 3190725 Document Number: 310884
It was previously reported that feeding rats on Steenbock and Black's rickets-inducing diet, deficient in vitamin D and with an altered calcium:phosphorus ratio, results in metabolic consequences and a marked decrease of sodium+-dependent D-glucose uptake at the jejunum-ileum level. To clarify the relation between experimental rickets and D-glucose uptake, 25-hydroxycholecalciferol (25-HCC) was given to rats fed on the rickets-inducing diet. In the jejunum-ileum, Na+-dependent D-glucose uptake returned to the values of the controls while the decrease in D-glucose uptake in the brush-border membrane vesicles prepared from kidney cortex of rachitic rats was not corrected by 25-HCC.