D-glucose uptake in intestinal brush-border membrane vesicles of rachitic rats
Treves, C.; Favilli, F.; Iantomasi, T.; Stio, M.; Vanni, P.; Vincenzini, M.T.
Biochemistry International 14(6): 1121-1132
1987
ISSN/ISBN: 0158-5231 PMID: 3453097 Document Number: 295620
We have previously reported the metabolic consequences of feeding rats Steenbock and Black's rickets-inducing diet, deficient in vitamin D and with an altered Ca/P ratio. Using isolated brush-border membrane vesicles prepared from the jejunum, ileum and duodenum of control and rachitic rats, we have demonstrated a marked decrease of Na+-dependent D-glucose uptake at jejunum-ileum level of rachitic rats. At duodenum level Na+-dependent D-glucose transport was not influenced by rickets. A lack of any significant difference between the two animal groups was observed studying the facilitated transport of D-glucose, the diffusion of L-glucose and the Na+-dependent uptake of phenylalanine and aspartate.