Hormonal and surgical treatment of endometrial adenocarcinoma
D'Addato, F.; Lanza, A.; Re, A.; Valli, M.; Raspollini, M.; Caldarola, B.; Allone, T.; Proserpio, D.; Ferraris, G.
European Journal of Gynaecological Oncology 9(3): 227-233
1988
ISSN/ISBN: 0392-2936 PMID: 3292240 Document Number: 309998
From January 1st, 1980 up to December 31st, 1986, 93 endometrial adenocarcinomas were treated at the Chair B of the Institute of Gynecology and Obstetrics. Full anatomopathological and hormonal data are available for 81 cases on whom diagnostic and therapeutic protocols were applied. In this selected group, positive lymph nodes were shown in 10 cases. Lymph node positivity was compared with myometrial infiltration grade: there were only two cases of lymph nodal positivity among 49 adenocarcinomas in which the invasion was more than 10 mm from the serosa, 8 lymph nodes metastases out of 32 adenocarcinomas with a distance between 10 and 5 mm and with distance less than 5 mm. The comparison with grading gives the following results: 6 node metastases on 70 G1 and G2 tumours, and 4 on 11 G3. We found 3 lymph nodal positivities both in the 9 cases with isthmus invasion and in the 12 cases with tubes involvement. The diagnostic and therapeutic surgical protocol includes hormonal therapy with oral MPA (1 g/die for 90 days and 500 mg/die for 12 months). Considering the results of preoperative hormonal therapy, two parameters (number of mitoses and FSH decreasing after MPA therapy) were selected with statistical evaluation.