Intraoperative sedation by midazolam during spinal anesthesia. a study of elderly women undergoing surgery of the hip and femur neck
Racle, J.P.; Cenon, E.; Jourden, L.; Benkhadra, A.; Poy, J.Y.; Fockenier, F.
Cahiers d'Anesthesiologie 36(5): 341-347
1988
ISSN/ISBN: 0007-9685 PMID: 3191417 Document Number: 308789
Midazolam was studied as an IV sedative agent in 30 women aged of 75 years or more, undergoing hip surgery or Ender nailing, who received a spinal anaesthesia with 15 mg of plain bupivacaine. A mean dose of midazolam 0.077 mg.kg-1 was required to induce adequate sedation which was maintained by repeated doses of 2.5 mg. Post-operatively, no somnolence was noted at 2 hr. A marked amnesic effect was observed in 77% of cases. No clinically adverse cardiovascular or respiratory effects were encountered. It is concluded that midazolam is a useful sedative agent for spinal anaesthesia of short duration in the elderly.